Synthace Ltd, the company behind Antha, the cloud-based software platform for automating and improving the success rate of biological processes, has launched a new software capability for streamlining a fundamental workhorse of biochemistry: the enzyme-linked immunosorbent assay (ELISA). Antha now allows researchers to flexibly design and execute automated ELISA protocols and automatically gather, structure, and analyze the data in an accessible, in-depth format, saving researchers valuable time from design to data acquisition.
A Powerful Detection Tool
ELISA protocols are ubiquitous in life science research but feature prominently in drug discovery, pathology (plant and animal), medical diagnostics, and quality control. Essentially, ELISAs use specific antibodies, like those generated by our immune system, to detect antigens and give off a detectable signal using an enzyme such as horseradish peroxidase. Without these assays, scientists would not be able to rapidly identify viral proteins, like in the HIV test, or detect potential allergens or toxins in food. An ELISA test for coronavirus was one of the first antibody detection methods available at the outset of the pandemic.
Shifting Bottlenecks and Reducing Burdens
ELISA protocols have repetitive liquid handling steps that lend themselves easily to automation. These complex protocols are often performed on multiple pieces of equipment that are not always physically connected. This creates several barriers: the scientist must know how to program all of the machines involved as well as acquire and process the data from them individually. Ultimately, automating ELISA assays reduces the time spent on liquid handling, but creates two new bottlenecks in programming and data handling.
To reduce the programming and data handling burdens for researchers, Synthace’s Antha acts as a single point of contact to perform the assay and acquire results. Antha is device-agnostic, with an intuitive user interface that allows scientists to design a flexible, end-to-end protocol and test it step-by-step in silico before sending it to the machines involved.
Changing How We Gather Data
In addition to showing the user a preview of the experiment, Antha automatically gathers tracks and structures data generated during the assays, even from non-integrated devices. At the conclusion of the protocol, Antha will generate a complete data analysis and visualization of these data automatically, saving time and resources spent gathering data and formatting it manually.
Clients trialing the new ELISA feature in Antha reported:
- 70% reduction in method programming time
- 81% reduction in assay design and analysis time
ELISAs are a critical assay across many fields within life science. As highly sensitive assays, they require precision and reproducibility that automation can provide. Flexible end-to-end approaches for ELISAs help scale key assays across many sectors, including biopharmaceutical development.
“This addition to our Antha platform will enable scientists to perform key assays reliably and reproducibly at scale. Most importantly, this will allow scientists to spend less time in the lab, enabling them to design better experiments, explore new insights, and ultimately increase the impact of their research,” concluded Dr. Tim Fell, CEO of Synthace.
Join the Synthace team on Friday, 16th October at 3pm BST / 10am EDT for a live demo to learn more about Antha-powered ELISAs and to ask our experts about automation, Antha, and more!
To learn more about automating ELISA protocols and getting the most from your data, visit: https://www.synthace.com/our-protocols/elisa-detail/
Based in London, UK, and Boston, the US, Synthace is accelerating biological discovery & optimization through computer-aided biology. Our cloud software platform, Antha, empowers biologists by enabling them to flexibly program their lab automation without the need to code. The graphical user interface has been designed by biologists for biologists, intuitively enabling them to automate their whole experiment from planning to execution, data collection, and analysis. Antha is the cornerstone of the lab of the future, seamlessly connecting the digital realm of data with the physical of lab automation and wet-lab biology, automatically collecting and structuring data to accelerate biological understanding.
Synthace is unlocking the potential of biology for humankind and our environment. Synthace works with biopharmaceutical companies, and in 2016 was recognized by the World Economic Forum as a Technology Pioneer that is helping shape the Fourth Industrial Revolution, and in 2018 as a cool vendor by Gartner.